解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his N...
journal_title:Archives of toxicology
pub_type: 历史文章,杂志文章
doi:10.1007/s00204-011-0728-8
更新日期:2011-12-01 00:00:00
abstract::The present study was designed to evaluate the possible protective effects of 3,3'-diselenodipropionic acid (DSePA), a potent radioprotector, against oxidative organ damage induced by whole body γ-irradiation and explore its mechanistic effects. The mice were subjected to whole body γ-irradiation at 5 Gy for the detec...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-011-0687-0
更新日期:2011-11-01 00:00:00
abstract::3-Chloro-1,2-propanediol (3-MCPD) fatty acid esters are formed upon thermal processing of fat-containing foods in the presence of chloride ions. Upon hydrolytic cleavage, these substances could release free 3-MCPD. This compound is toxicologically well characterised and displayed cancerogenic potential in rodent model...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-011-0657-6
更新日期:2011-10-01 00:00:00
abstract::This review provides a compendium of the results of genotoxicity and carcinogenicity assays performed on marketed antihistamines. Of the 70 drugs examined, 29 (41.4%) have at least one genotoxicity and/or carcinogenicity test result: 12 tested positive in at least one genotoxicity assay, six in at least one carcinogen...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-011-0659-4
更新日期:2011-10-01 00:00:00
abstract::Thanks to the confluence of genome sequencing and bioinformatics, the number of metabolic databases has expanded from a handful in the mid-1990s to several thousand today. These databases lie within distinct families that have common ancestry and common attributes. The main families are the MetaCyc, KEGG, Reactome, Mo...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-011-0705-2
更新日期:2011-09-01 00:00:00
abstract::As part of a study on cadmium nephrotoxicity, we studied the effect of cadmium chloride (CdCl2) in isolated human renal proximal tubules metabolizing the physiological substrate lactate. Dose-effect experiments showed that 10-500 μM CdCl2 reduced lactate removal, glucose production and the cellular levels of ATP, coen...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0633-6
更新日期:2011-09-01 00:00:00
abstract::This study was conducted to determine the functional role of phospholipase D (PLD) involved in testicular Leydig cell damage caused by di (2-ethylhexyl) phthalate (DEHP) in Sprague-Dawley rats. DEHP (500 mg/kg/day) was administered orally to prepubertal rats for 1, 7, 14, 21 or 28 days. After 7 days of exposure, DEHP ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0618-5
更新日期:2011-08-01 00:00:00
abstract::The use of nanotechnology is increasing exponentially, whereas the possible adverse health effects of engineered nanoparticles (NPs) are so far less known. Standardized mouse bioassay was used to study sensory and pulmonary irritation, airflow limitation, and inflammation potency of nanosized TiO(2). Single exposure (...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-011-0644-y
更新日期:2011-07-01 00:00:00
abstract::The in ovo carcinogenicity assessing (IOCA) assay was used to examine the morphological changes in fetal turkey livers caused by the DNA-reactive carcinogen diethylnitrosamine (DEN). Fertilized turkey eggs were allocated into 3 groups: nondosed control (NDC), vehicle (water) control (VC) and DEN-dosed. At day 0, the f...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0603-z
更新日期:2011-06-01 00:00:00
abstract::The routinely used analytical method for detecting the abuse of anabolic steroids only allows the detection of molecules with known analytical properties. In our supplementary approach to structure-independent detection, substances are identified by their biological activity. In the present study, urines excreted afte...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0590-0
更新日期:2011-04-01 00:00:00
abstract::The objective of this study was to evaluate the role of apoptosis in the development of the newborn cochlear structures and hearing loss caused by prenatal cis-diaminedichloroplatinum (cisplatin) exposure. Pregnant albino guinea pigs were intraperitoneally injected with 1.5 mg/kg body weight cisplatin once a day for s...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0543-7
更新日期:2011-01-01 00:00:00
abstract::Selenium (Se) is an essential dietary component for animals including humans and is regarded as a protective agent against cancer. Although the mode of anticancer action of Se is not fully understood yet, several mechanisms, such as antioxidant protection by selenoenzymes, specific inhibition of tumor cell growth by S...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-010-0595-8
更新日期:2010-12-01 00:00:00
abstract::Phenethyl isothiocyanate is a chemopreventive phytochemical present in cruciferous vegetables where it exists as the glucosinolate gluconasturtiin. It is a mechanism-based inhibitor of both rat and human cytochrome P450 enzymes. The principal objective of the present study was to ascertain whether phenethyl isocyanate...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0522-z
更新日期:2010-10-01 00:00:00
abstract::The trichothecene mycotoxin deoxynivalenol (DON) is produced in wheat, barley and corn following infestation by the fungus Fusarium in the field and during storage. Colloquially known as "vomitoxin" because of its emetic effects in pigs, DON has been associated with human gastroenteritis. Since DON is commonly detecte...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-010-0579-8
更新日期:2010-09-01 00:00:00
abstract::Arsenic has been a recognized contaminant and toxicant, as well as a medicinal compound throughout human history. Populations throughout the world are exposed to arsenic and these exposures have been associated with a number of human cancers. Not much is known about the role of arsenic as a human carcinogen and more r...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-010-0554-4
更新日期:2010-08-01 00:00:00
abstract::Exposure to toxic metals is a well-known problem in industrialized countries. Metals interfere with a number of physiological processes, including central nervous system (CNS), haematopoietic, hepatic and renal functions. In the evaluation of the toxicity of a particular metal it is crucial to consider many parameters...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-010-0544-6
更新日期:2010-07-01 00:00:00
abstract::Neuropathy Target Esterase (NTE) was initially identified as the primary target esterase of some organophosphorus compounds that cause delayed neuropathy. Some studies in vivo suggest that this protein may also perform a function in embryonic development and therefore also in cell differentiation. The aim of this work...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0518-8
更新日期:2010-06-01 00:00:00
abstract::Many in the welding industry suffer from bronchitis, lung function changes, metal fume fever, and diseases related to respiratory damage. These phenomena are associated with welding fumes; however, the mechanism behind these findings remains to be elucidated. In this study, the lungs of cynomolgus monkeys were exposed...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0486-z
更新日期:2010-03-01 00:00:00
abstract::The hypothesis that methylmercury (MeHg) potently induces formation of reactive oxygen species (ROS) in the brain is supported by observations on the neuroprotective effects of various classes of antioxidants. Flavonoids have been reported to possess divalent metal chelating properties, antioxidant activities and to r...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0482-3
更新日期:2010-02-01 00:00:00
abstract::Insulin-exposed rat mammary cancer cells were flow sorted based on a c-myc reporter plasmid encoding a destabilized green fluorescent protein. Sorted cells exhibited gradual increases in c-myc levels. Cells overexpressing c-myc by only 10% exhibited phenotypic changes attributable to c-myc overexpression, such as cell...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0463-6
更新日期:2009-12-01 00:00:00
abstract::Menadione is a naphthoquinone used as a vitamin K source in animal feed that can generate reactive oxygen species (ROS) and cause apoptosis. Here, we examined whether menadione reduces development of preimplantation bovine embryos in a ROS-dependent process and tested the hypothesis that actions of menadione would be ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0458-3
更新日期:2009-11-01 00:00:00
abstract::4-Nonylphenol (para-nonylphenol, 4-NP), metabolites including linear and branched isoforms of nonylphenol (n-NP and t-NP, respectively), has been considered an endocrine disrupting substance resulting in reproductive dysfunction and increasing reactive oxygen species production in testis, liver, kidney, and brain. How...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0447-6
更新日期:2009-10-01 00:00:00
abstract::We investigated the hepatotoxicity induced by AQ using a glutathione (GSH)-depleted mice model. Although sole administration of either AQ or L-buthionine-S,R-sulfoxinine (BSO), a well-known GSH synthesis inhibitor, produced no significant hepatotoxicity, combined administration of AQ with BSO induced hepatotoxicity ch...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0436-9
更新日期:2009-07-01 00:00:00
abstract::To evaluate the developmental neurotoxicity of arsenic in offspring rats by transplacental and early life exposure to sodium arsenite in drinking water, the pregnant rats or lactating dams, and weaned pups were given free access to drinking water, which contained arsenic at concentrations of 0, 10, 50, 100 mg/L from G...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0403-5
更新日期:2009-06-01 00:00:00
abstract::Chronic exposure to carbon disulfide (CS2) can induce polyneuropathy in occupational worker and experimental animals, but underlying mechanism for CS2 neurotoxicity is currently unknown. In the present study, male Wistar rats were randomly divided into two experimental groups and one control group. The rats in two exp...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0399-2
更新日期:2009-06-01 00:00:00
abstract::A dual-label time-resolved fluoroimmunoassay (TRFIA) for simultaneous quantification of aflatoxin B1 (AFB1) and ochratoxin A (OTA) is described. For this, microtitration wells were coated with AFB1-horse radish peroxidase (HRP) and OTA-bovine serum albumin. The standards and samples were loaded on the coated plates, a...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0410-6
更新日期:2009-06-01 00:00:00
abstract::The aim of this study was to assess the neurotoxicity of diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells. When used at concentrations of 1, 5 and 10 microM, DZO did not cause cell death but it impaired the outgrowth of...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0339-1
更新日期:2009-04-01 00:00:00
abstract::The present study was performed to investigate the potential toxic effects of prenatal exposure to 4-tert-octylphenol (OP) on liver, kidney, spleen, and hematologic parameters of male and female rats in adult life. The rats were treated with OP subcutaneously in utero at doses of control (vehicle, corn oil), 100 or 25...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0354-2
更新日期:2009-04-01 00:00:00
abstract::The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We s...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0364-0
更新日期:2009-03-01 00:00:00
abstract::Tea (Camellia sinensis, Theaceace), a popular beverage consumed world-wide, has been studied for its preventive effects against cancer as well as cardiovascular, neurodegenerative, and other diseases. Most of the proposed beneficial effects have been attributed to the polyphenolic compounds in tea, but the nature of t...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-008-0372-0
更新日期:2009-01-01 00:00:00
abstract::The amphetamine-derived designer drugs have been illegally used worldwide as recreational drugs, some of which are known to be hepatotoxic in humans. To compare their cytotoxic effects, 3,4-methylenedioxy-N-methamphetamine (MDMA) and its related analogues, N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), 3,4...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0323-9
更新日期:2009-01-01 00:00:00
abstract::We recently showed that prenatal exposure to diesel exhaust (DE) disrupts spermatogenesis in mouse offspring. This study was undertaken to determine whether filtered DE in which 99.97% of diesel exhaust particles >0.3 microm in diameter were removed affects spermatogenesis in growing mice. After prenatal exposure to f...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0302-1
更新日期:2008-11-01 00:00:00
abstract::Regarding the cancer risk assessment of acrylamide (AA) it is of basic interest to know, as to what amount of the absorbed AA is metabolized to glycidamide (GA) in humans, compared to what has been observed in laboratory animals. GA is suspected of being the ultimate carcinogenic metabolite of AA. From experiments wit...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0296-8
更新日期:2008-10-01 00:00:00
abstract::The present study has investigated the ability of amitraz, a widely used formamidine pesticide, to modulate serum concentrations and liver microsomal metabolism of 17beta-estradiol (E2) and testosterone in rats. Amitraz was administered intraperitoneally to male rats for 4 days and to intact female rats or ovariectomi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0288-8
更新日期:2008-10-01 00:00:00
abstract::In order to clarify the possible mechanism of hepatocarcinogenesis induced by piperonyl butoxide, we attempted to identify the transcription factor activated by piperonyl butoxide in the male ICR mouse liver. Administration of 0.6% piperonyl butoxide for 24 h elevated the level of liver nuclear proteins that bind to a...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0283-0
更新日期:2008-10-01 00:00:00
abstract::To clarify whether oxidative stress is involved in the development of hepatocellular preneoplastic foci induced by fenofibrate (FF), a peroxisome proliferator-activated receptor alpha agonist, male F344/N rats were fed a diet containing 6,000, 3,000, or 0 ppm of FF for 13 weeks after N-diethylnitrosamine initiation. T...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0278-2
更新日期:2008-09-01 00:00:00
abstract::Carcinogenic risk and molecular mechanisms underlying the liver tumor-promoting activity of copper gluconate, an additive of functional foods, were investigated using a rat medium-term liver carcinogenicity bioassay protocol (Ito test) and a 2-week short-term administration experiment. In the medium-term liver bioassa...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-008-0294-x
更新日期:2008-08-01 00:00:00
abstract::Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log(10) blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the med...
journal_title:Archives of toxicology
pub_type: 杂志文章,meta分析
doi:10.1007/s00204-008-0292-z
更新日期:2008-08-01 00:00:00
abstract::Sulfur mustard (SM) is a bifunctional alkylating agent. Its primary toxic consequence is severe skin damage with blisters, occurring after skin contact. These vesicant properties of SM have been linked to cell death of proliferating keratinocytes in the basal layer of the skin. Catalytic activation of the nuclear enzy...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0265-7
更新日期:2008-07-01 00:00:00
abstract::This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a sh...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0255-9
更新日期:2008-06-01 00:00:00